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COMPRENDO as an interdisciplinary, integrated approach addresses endocrine disruption in human and wildlife species, focussed on
androgenic/antiandrogenic compounds (AACs). The project will identify human and environmental exposures to AACs. A variety
of human-relevant models (cell lines, tissues, rodents) and wildlife species (amphibians, fish, echinoderms, crustaceans, molluscs) will
be exposed to 13 chemicals and various environmental samples to develop new biological effect measures, including a molecular
screen for genomic AAC effects. Common principles of AAC action will be identified and new models for the extrapolation on
human health developed. Lab cultures of suitable invertebrates will be established and their baseline endocrinology analysed,
facilitating the use of these species as standard test organisms. Finally, an evaluation of the risk originating from AACs for
humans and wildlife will be performed.
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